The appearance of an obvious effect requires daily administration for four months. Achieving the maximum effect (generally, doubling the effect from 4-6 months of treatment) is achieved during the 8-12 months of treatment. Maintaining this effect requires continued administration of a maintenance dose (1 ml once a day)
1 ml (8 puffs) twice a day, applied to affected areas. The maximum daily dose should not exceed 2 ml.